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Genzyme Corporation, ranked as one of the foremost biotechnology companies 
in the world, is committed to providing an exceptional environment in which 
individuals can excel, and achieve their professional and personal goals. 
Genzyme Corporation has been selected by FORTUNE magazine as one of 
the "100 Best Companies to Work For in 2006 in the United States”. By 
applying for a position with Genzyme, you are taking the first step toward 
becoming a part of our dynamic and talented team, and sharing in our 
continued success.

Staff Scientist I  - Requisition # 10796

The confocal microscopy group within the Genzyme Pathology collaborates 
with investigators and other members of the confocal group to design and 
implement animal model- and cell culture-based studies utilizing advanced 
microscopy techniques as the primary readout. Imaging modalities to be 
utilized include human interactive and automated confocal microscopy, 
fluorescence correlation spectroscopy, time lapse recording, macroscopy, 
widefield fluorescence microscopy and structured illumination. In this position, 
development of fluorescence-based assays, custom image analysis algorithms, 
and downstream statistical tools will be used to extract biological information 
from image datasets. Biological interpretation, report writing, communication of 
results to investigators, and quality control will be critical aspects of the 
position. The position will involve mostly team-based work with some 
opportunity for independent research. You will interact with diverse groups in 
the Genzyme Science and Manufacturing organizations. Imaging/image analysis 
approaches currently used within the group include confocal microscopy, 
fluorescence correlation spectroscopy, high content analysis, widefield 
microscopy with or without structured illumination, brightfield and fluorescence 
macroscopy, and development of custom image analysis algorithms using a 
variety of software packages. 

Basic Qualifications:  PhD in cell biology or the life sciences and a maximum of 
3 years academic or industrial laboratory experience.  Requires 2+ years  cell 
culture and immunofluorescence/ immunohistochemistry staining experience.

Preferred Qualifications:  Thorough understanding of the principles of confocal 
and widefield fluorescence microscopy, cell biological processes and basic 
tissue architecture.   Rigorous experimental design experience and able to 
develop and troubleshoot novel fluorescence-based assays.  One or more 
years experience using Metamorph, Imaris, and/or Matlab image analysis 
software and 1 or more years experience with Visual Basic programming.   One 
or more years experience using standard biochemical and molecular biological 
techniques such as in situ hybridization, PCR, agarose gel electrophoresis, 
standard subcloning and restriction analysis, preparation of protein extracts 
from cells and tissues, immunoprecipitation, SDS-PAGE and Western blot 
analysis will also be helpful.  Excellent interpersonal and communication skills.

To apply for this position please go to our website at 
www.genzyme.com/careers and enter job number 10796.