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Steffen Dietzl mentioned this a while ago in a lab class discussion:
"There used to be a paper microscope with plastic lenses on the German
market, for about 10-15 Euro (ISBN 3935364083) but the assembly took a
little long for the course (4-6 h), so I dropped that. It did deliver a
surprisingly good quality though."
That was the first time I read about paper microscopes.
With the same motivation as Manu Prakash, a nice paper here, using the
halogen lamp for fluorescence:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031638
and surely also relevant for a minimal-cost microscopy approach (but on the
other side of the eyepiece):
http://www.malariajournal.com/content/11/1/352
_____________________________________
Philippe Laissue, PhD, Bioimaging Manager
School of Biological Sciences, Room 4.17
University of Essex, Colchester CO4 3SQ, UK
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On 17 March 2014 12:43, Guy Cox <[log in to unmask]> wrote:
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>
> I'm sure I remember a paper compound microscope from many years ago.
> Obviously no LED illuminator. I think you squeezed a bellows-folded
> section to focus. Anyone else remember this, or am I the last left
> standing?
>
> Guy
>
> -----Original Message-----
> From: Confocal Microscopy List [mailto:[log in to unmask]]
> On Behalf Of Steffen Dietzel
> Sent: Monday, 17 March 2014 8:58 PM
> To: [log in to unmask]
> Subject: Re: A paper microscope?
>
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>
> Am 16.03.2014 16:07, schrieb John Oreopoulos:
> > Apparently there are brightfield, darkfield, phase contrast, and even
> fluorescence versions available. And I ask, can one make a confocal version
> of this?
>
> Well, this is a simple microscope, not a compound one. So there is no
> intermediate image and thus no plane where one could place the detection
> pinhole. Therefore, the short answer is no, you can't make a confocal
> version.
>
> Of course, one could try to redesign the whole thing. One would probably
> need a more stable stand to ensure a fixed tube length. Or, use infinity
> optics. What to use for detector? Maybe a smartphone camera in a
> spinning disk version? I guess in any case we would move far far away
> from the <1$ goal. Still might be an interesting and fun-project to try...
>
> Here are some designs to try, from the 1960ies, so the patent is
> expired. One is with Nipkow-disks, another with double-sided mirror
> which is used for scanning and descanning.
> https://commons.wikimedia.org/wiki/File:KlausWeber-USPatent3518014-Fig7.png
> (see also other images linked on the page)
>
> I guess the images are sort of self-explanatory to the confocalist. For
> an English description, you have to click on the linked patent
> application, a short German description can be found here:
>
> https://de.wikipedia.org/wiki/Konfokalmikroskop#1966:_.E2.80.9EVorrichtung_zur_optischen_Abtastung_mikroskopischer_Objekte.E2.80.9C
>
> The fun part would be to figure out how to build a confocal really
> cheap. Let's not think about whether it would be worth it, that'd
> probably spoil the whole approach...
>
> Cheers,
>
> Steffen
>
>
>
> --
> ------------------------------------------------------------
> Steffen Dietzel, PD Dr. rer. nat
> Ludwig-Maximilians-Universität München
> Walter-Brendel-Zentrum für experimentelle Medizin (WBex)
> Head of light microscopy
>
> Mail room:
> Marchioninistr. 15, D-81377 München
>
> Building location:
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>
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