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Hi all,
As a light sheet microscope's detection is widefield, the overall penetration depth 
of the system will be limited to less than one scattering mean free path (~in the 
order of 100 microns for most tissues). This might be reached in the Zeiss 
youtube example and hence things get very blurry.

A two-photon scanning microscope can go up to 5 scattering path lengths, the 
strehl ratio will be much reduced, but you can still see cells.

Best,
Reto