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Hi all, 

Hm.  The Betzig group went live cell first in Nature Methods 5:155 and
5:417 (2008), but the Zhuang group did compelling work in PNAS 109:13978
(2012) that also broke ground in live imaging involving localization
microscopy.  I think the three name limit put the Committee in a very hard
spot here.  

Best, 


Tim

Timothy Feinstein, Ph.D. | Confocal Manager
333 Bostwick Ave., N.E., Grand Rapids, Michigan 49503
Phone: 616-234-5819 | Email: [log in to unmask]







On 10/8/14, 10:10 AM, "Martin Wessendorf" <[log in to unmask]> wrote:

>*****
>To join, leave or search the confocal microscopy listserv, go to:
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>PeV-TaQ&u=http%3a%2f%2flists%2eumn%2eedu%2fcgi-bin%2fwa%3fA0%3dconfocalmic
>roscopy
>Post images on 
>http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_ebn
>OK1XHOQ&u=http%3a%2f%2fwww%2eimgur%2ecom and include the link in your
>posting.
>*****
>
>Dear Dr. Xi--
>
>Excellent question, especially since Rust et al 2006 was accepted and
>published on-line a day or two prior to Beitzig et al 2006. --Here's the
>statement by the chairman of the Nobel committee:
>http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_eej
>BflCROA&u=http%3a%2f%2fwww%2enobelprize%2eorg%2fnobel%5fprizes%2fchemistry
>%2flaureates%2f2014%2fannouncement%2ehtml
>. --According to him, the rationale for the Prize was that STED and PALM
>can be used to view biochemistry happening in living organisms.
>
>Do any of our Swedish members have insight into how these decisions are
>made?
>
>Martin Wessendorf
>
>
>
>On 10/8/2014 7:52 AM, Peng Xi wrote:
>> Why not Xiaowei Zhuang?
>>
>>
>> Sincerely,
>> Peng Xi
>> Ph. D.    Associate Professor
>> Dept. of Biomedical Engineering, College of Engineering
>> Peking University, Beijing, China
>> Tel: +86 10-6276 7155
>> Email: [log in to unmask]
>> 
>>http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_eb
>>rBKV7FMA&u=http%3a%2f%2fbme%2epku%2eedu%2ecn%2f%7exipeng%2f
>>
>> On Wed, Oct 8, 2014 at 7:51 AM, George McNamara
>><[log in to unmask]>
>> wrote:
>>
>>> *****
>>> To join, leave or search the confocal microscopy listserv, go to:
>>> 
>>>http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_e
>>>ezPeV-TaQ&u=http%3a%2f%2flists%2eumn%2eedu%2fcgi-bin%2fwa%3fA0%3dconfoca
>>>lmicroscopy
>>> Post images on 
>>>http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_e
>>>bnOK1XHOQ&u=http%3a%2f%2fwww%2eimgur%2ecom and include the link in your
>>>posting.
>>> *****
>>>
>>> congratulations to Eric, Stefan and W.E. for Nobel Prize in Chemistry
>>>
>>> 
>>>http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_e
>>>b7KIwPFOA&u=http%3a%2f%2fwww%2enobelprize%2eorg%2fnobel%5fprizes%2fchemi
>>>stry%2flaureates%2f2014%2fpress%2ehtml
>>>
>>>
>>>   Press Release
>>>
>>> 8 October 2014
>>>
>>> The Royal Swedish Academy of Sciences
>>><http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_
>>>eb3LfQSWaQ&u=http%3a%2f%2fwww%2enobelprize%2eorg%2f
>>> redirect/links_out/prizeawarder.php?from=/nobel_
>>> prizes/chemistry/laureates/2014/press.html&object=kva&to=
>>> 
>>>http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_e
>>>b6dflWUbg&u=http%3a%2f%2fwww%2ekva%2ese%2fen%2f> has decided to award
>>>the Nobel Prize in Chemistry
>>> for 2014 to
>>>
>>> *Eric Betzig*
>>> Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn,
>>> VA, USA,
>>>
>>> *Stefan W. Hell*
>>> Max Planck Institute for Biophysical Chemistry, Göttingen, and German
>>> Cancer Research Center, Heidelberg, Germany
>>>
>>> and
>>>
>>> *William E. Moerner*
>>> Stanford University, Stanford, CA, USA
>>>
>>> /³for the development of super-resolved fluorescence microscopy²/
>>>
>>>
>>>     Surpassing the limitations of the light microscope
>>>
>>> For a long time optical microscopy was held back by a presumed
>>>limitation:
>>> that it would never obtain a better resolution than half the
>>>wavelength of
>>> light. Helped by fluorescent molecules the Nobel Laureates in Chemistry
>>> 2014 ingeniously circumvented this limitation. Their ground-breaking
>>>work
>>> has brought optical microscopy into the nanodimension.
>>>
>>> In what has become known as nanoscopy, scientists visualize the
>>>pathways
>>> of individual molecules inside living cells. They can see how molecules
>>> create synapses between nerve cells in the brain; they can track
>>>proteins
>>> involved in Parkinson¹s, Alzheimer¹s and Huntington¹s diseases as they
>>> aggregate; they follow individual proteins in fertilized eggs as these
>>> divide into embryos.
>>>
>>> It was all but obvious that scientists should ever be able to study
>>>living
>>> cells in the tiniest molecular detail. In 1873, the microscopist Ernst
>>>Abbe
>>> stipulated a physical limit for the maximum resolution of traditional
>>> optical microscopy: it could never become better than 0.2 micrometres.
>>> *Eric Betzig*, *Stefan W. Hell* and *William E. Moerner* are awarded
>>>the
>>> Nobel Prize in Chemistry 2014 for having bypassed this limit. Due to
>>>their
>>> achievements the optical microscope can now peer into the nanoworld.
>>>
>>> Two separate principles are rewarded. One enables the method
>>>/stimulated
>>> emission depletion (STED) microscopy/, developed by Stefan Hell in
>>>2000.
>>> Two laser beams are utilized; one stimulates fluorescent molecules to
>>>glow,
>>> another cancels out all fluorescence except for that in a
>>>nanometre-sized
>>> volume. Scanning over the sample, nanometre for nanometre, yields an
>>>image
>>> with a resolution better than Abbe¹s stipulated limit.
>>>
>>> Eric Betzig and William Moerner, working separately, laid the
>>>foundation
>>> for the second method, /single-molecule microscopy/. The method relies
>>>upon
>>> the possibility to turn the fluorescence of individual molecules on and
>>> off. Scientists image the same area multiple times, letting just a few
>>> interspersed molecules glow each time. Superimposing these images
>>>yields a
>>> dense super-image resolved at the nanolevel. In 2006 Eric Betzig
>>>utilized
>>> this method for the first time.
>>>
>>> Today, nanoscopy is used world-wide and new knowledge of greatest
>>>benefit
>>> to mankind is produced on a daily basis.
>>>
>>>
>>> //
>>>
>>> My thanks to the Nobel committee for revealing what W.E. is.
>>>
>>> --
>>>
>>>
>>>
>>> George McNamara, Ph.D.
>>> Single Cells Analyst
>>> L.J.N. Cooper Lab
>>> University of Texas M.D. Anderson Cancer Center
>>> Houston, TX 77054
>>> Tattletales 
>>>http://scanmail.trustwave.com/?c=129&d=ksa11D595nB9lxX7ILvNZUmUIR93pRN_e
>>>ePLeAaSbQ&u=http%3a%2f%2fworks%2ebepress%2ecom%2fgmcnamara%2f42
>>>
>
>-- 
>Martin Wessendorf, Ph.D.                   office: (612) 626-0145
>Assoc Prof, Dept Neuroscience                 lab: (612) 624-2991
>University of Minnesota             Preferred FAX: (612) 624-8118
>6-145 Jackson Hall, 321 Church St. SE    Dept Fax: (612) 626-5009
>Minneapolis, MN  55455                    e-mail: [log in to unmask]