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Dear Karl,
I think your statement "Windows has severe limitations when working with
large datasets" is untrue.
I recently demo'ed Autoquant's suite of 2D/3D/4D image processing
software for Windows and it was superb. I easily manipulated stacks of
12-bit images totalling atleast 2 Gigs. I do agree, though, that
Improvision's Volocity is a very nice product.
The journaling in Metamorph blows Openlab out of the water - if you're
prepared to invest a little time learning it. I've also found the
software support at Universal Imaging Corporation (Molecular Devices) to
be excellent. And its free once you've purchased Metamorph - unlike the
high cost of Improvision's service license agreement for Openlab and
Volocity.
Cheers, John